Preformulation Studies of the γ-Cyclodextrin and Montelukast Inclusion Compound Prepared by Comilling. Abstract Montelukast (MLK), an oral antiasthmatic drug with growing use, requires special care in formulation and storage to avoid its degradation by action of light and water. This work investigates the increase in the stability of montelukast as the effect of molecular encapsulation…

Vibrational dynamics of 4-fluorobenzaldehyde from periodic DFT calculations. Abstract A thorough vibrational portrait of 4-fluorobenzaldehyde is presented, covering Infrared (Mid- and Far-), Raman and Inelastic Neutron Scattering (INS) spectra. Periodic DFT calculations (CASTEP) of a model 4FB crystal proved useful for vibrational assignment, yielding estimates of experimental spectra with near one-to-one correspondence – including the…

Understanding the vibrational spectra of crystalline isoniazid: Raman, IR and INS spectroscopy and solid-state DFT study Abstract This work presents a comprehensive spectroscopic analysis of crystalline isoniazid, one of the main drugs in tuberculosis chemotherapy, using a blend of spectroscopic and computational methods. Mid-and far-infrared, Raman, and inelastic neutron scattering spectroscopies, with contribution of isotopic…

Espectro Abstract A spectrum is a graphical representation of the magnitude of the radiation-matter interaction (intensity) as a function of the energy of that radiation. Thus, the ordinate axis in a spectrum is always indicative of the intensity of the signal recorded in the detector (often in arbitrary units and only with a relative value),…